Ann Patchett, who held readers captive with Bel Canto, her 2001 novel about a famous opera singer and a group of international dignitaries taken hostage by Latin American terrorists, is back in form with her mesmerizing sixth novel, State of Wonder. Set in the Amazon rain forest, Patchett's new book is a dramatic, transportive adventure story that takes on issues of medical ethics, cultural respect, friendship, love and loyalty.